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N13 - Zoom Virtual Networking Room
Exosomes and other Extracellular Vesicles in Transplant Tolerance

Tuesday September 15, 2020 | 13:00 to 14:30
Room: Networking 5
Track: N/A

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The dynamics of the host-donor relationship in transplants revolve around production by the graft and host of immune signals that promote either rejection or tolerance. We now know that EV/exosomes are critical for the tremendous amplification of immunogenicity leading to acute allograft rejection. Other work suggests that EV/exosomes may also promote tolerance. The session will go into the mechanisms of tolerance induced by EV/exosomes from a) DC or DCreg, b) T cells or Treg, and c) B cells or Bregs. The mediators of tolerance carried by these EV/exosomes include: 1) miRNA, inducing PD-L1 in DC; 2) extracellular ATPase/ADPase [CD39/CD73], 3) CD81-bound exosomal IL35. The audience will hear updates on recent progress in this field, and how the interplay of EV/exosomes from donor organ and recipient can promote "infectious" tolerance both locally and systemically.


William J. Burlingham, United States

Gilles Benichou, United States

Charles Egwaugu, United States

Adrian E. Morelli, United States

Lesley Smyth, United Kingdom

Jeremy Sullivan, United States

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