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Kidney Transplantation: Novel approaches to monitoring

Tuesday September 15, 2020 - 23:30 to 00:15

Room: Channel 11

410.3 Analysis of the difference of the monitoring results of TCR high variable area in renal transplant recipients after treatment with different immune induction schemes

Tian Puxun, People's Republic of China

Hospital of Nephropathy, First Affiliated Hospital of Medical College of Xi’an Jiaotong University

Abstract

Analysis of the difference of the monitoring results of TCR high variable area in renal transplant recipients after treatment with different immune induction schemes

Tian Puxun1, Han Feng1, Dou Meng1, Zheng Bingxuan1, Deng Ge1, Ding Xiaoming1, Xue Wujun1.

1Department of Kidney Transplantation, Hospital of Nephropathy, First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi'an, People's Republic of China

Objective: To observe and summarize the effect of different induction schemes on the highly variable region of T-lymphocyte receptor (TCR) in living relative renal transplant recipients.
Method: According to the early use of immune-induced antibody, 12 living relative kidney transplant recipients were divided into three groups: baliximab group (BLX group, 4 cases), Rabbit anti human thymus immunoglobulin group (rATG group, 4 cases) and methylprednisolone group (MP group, 4 cases). The immune group library was established to analyze the three days before operation (before administration) and one week, two weeks and one month after operation Blood TCR-CDR3 Clone Diversity, clone frequency, clone change mode and other differences, and through the correlation with the expression of immune related markers, analyze the differences of results in each group and the possible clinical significance.
Result: There were no acute rejection and 2 cases of mild infection in rATG group. The clonal diversity, clonal frequency, clonal change mode and some immune markers of TCR-CDR3 were changed in all groups and groups, especially in rATG group.
Conclusion: The expression profile of TCR-CDR3 in the peripheral blood of recipients showed different expression characteristics after the application of different immune induction schemes, which was related to the change of immune status to a certain extent. It may become a detection method with predictive value for infection or rejection in living relative kidney transplant recipients.
Keywords: Living-related renal transplantation;TCR ; Gene; Immune State

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