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Kidney

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Room: E-Poster Hall

P-11.176 Survival analysis in the presence of competing risks in kidney transplant

Jessica J Pinto Ramirez PR, Colombia

Transplant Nephrology
Kidney Transplant
Colombiana de Trasplantes

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Abstract

Survival analysis in the presence of competing risks in kidney transplant

Sergio Salcedo1, Andrea Garcia1, Nasly Patiño1, Jefferson Barbosa1, Sergio Riveros1, Juan Garcia1, Jessica Pinto Ramirez1, Fernando Giron1.

1Kidney Transplantation , Colombiana de Trasplantes, Bogota, Colombia

Background: Chronic kidney disease (CKD) is a multisystemic pathology with great clinical impact on the quality of life of patients and their families; and commits approximately 10% of the world's population.
In patients with stage 4 and 5, kidney transplantation is the therapy choice; it has shown improvement towards quality of life, survival and decrease in costs.
The survival of a functional graft has been described around 88% at 5 years and 72-87% at 10 years; however, new statistical models for analyzing survival data have recently been developed.
Objective: Describe the survival of the renal graft between the conventional survival analysis and the competitive risk analysis
Methods: A retrospective analytical study of a historical cohort in Colombiana de Trasplantes, Bogota Colombia, was carried out, including transplant patients between 2008-2019.
Results: 1520 subjects included, 619 receiving patients were women (40.7%). The average age of the patients was 43.58 +/- 13.23 years. Absolute risk of graft loss by conventional survival analysis was 73% at ten years and competing-risk analysis .was 75% at ten years. The risk calculated by conventional methods reflects a hypothetical scenario in which graft loss and all other events are censored. The risk calculated by competing-risk analysis reflects the probability of a graft loss in a real-world scenario, whereby death from other causes is taken into account.

Conclusions: When estimating probability of long term graft survival and death, competing risk analysis gives more accurate measure in subgroups with different rate of competing event.
Keywords: Kidney trasplantation, graft survival, registry-based studies, retrospective studies.

References:

[1] Costo CDEA. LA ENFERMEDAD RENAL CRÓNICA, LA HIPERTENSIÓN ARTERIAL Y LA DIABETES MELLITUS en Colombia. 2017; Available from: https://cuentadealtocosto.org/site/images/Publicaciones/Situacion_ERC_HA_DM_Colombia_2016.pdf
[2] Martínez-Mier G, Ávila-Pardo SF, Irigoyen-Castillo A, Rodríguez-Fernández A, Jiménez-López LA, Varela-Pérez V. Análisis de la supervivencia a 10 años de trasplante renal en el Hospital de Alta Especialidad de Veracruz. Artículo Orig [Internet]. 2016;5:113–9. Available from: http://www.medigraphic.com/trasplantes%0Awww.medigraphic.org.mx
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Presentations by Jessica J Pinto Ramirez PR

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