Liver transplantation for primary sclerosing cholangitis
Aydincan Akdur1, Emre Karakaya1, Fatih Boyvat2, Sedat Yildirim1, Kenan Caliskan1, Mehmet Haberal1.
1Transplantation, Baskent University, Ankara, Turkey; 2Interventional Radiology, Baskent University, Ankara, Turkey
Introduction: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown origin. Liver transplantation (LT) is require in more than half of this patients. In this study, we analyzed our results in the patients with LT owing to PSC.
Materials and Methods: A total of 649 LT were performed in our center between December 1988 and December 2019. The results were retrospectively analyzed from 12 patients, who underwent LT for PSC. Demographic features, presence of any concomitant inflammatory bowel disease (IBD), time to LT, and outcome data were recorded.
Results: There were 12 patients (8 men and 4 women). Ten of the patients were adult and 2 of them were pediatric patient. Mean age of these patients was 27 ± 12 (range, 5 to 40 years). Seven of the transplantations were living donor liver transplantation. Mean follow-up period was 123±49 months. Bile duct reconstruction was performed with hepaticojejunostomy in 7 patients and duct to duct in 5 patients. Biliary leakage was detected in 4 patients postoperatively and they were treated with interventional radiological techniques successfully. Biliary stenosis developed in 4 patients in the late period and 3 of them were treated with interventional radiological methods. In 1 patient surgical treatment was applied. In 1 patient PSC recurred 11 years after LT and retransplantation was performed. Two patients passed away during the follow up period due to sepsis.
Conclusions: LT in PSC resulted in favorable outcomes regarding postoperative morbidity and mortality compared with other etiologies.
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