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Mon Sep 14

08:15 - 10:00 Workshop Session: Beta Cell Replacement around the World - Where are we as a global community?
263.1 Beta Cell Replacement around the World - Where are we as a global community
Thomas Kay, Australia
263.2 How can we teach/learn from one another to develop pancreas transplantation?
Duck Jong Han, Korea
Byung-Hyun Choi, Korea
263.3 What are the bottleneck and hurdles to overcome to expand beta cell replacement?
Hussein Khambalia, United Kingdom
15:15 - 17:00 State-of-the-Art Session: Islet Transplantation Up-to-Date
293.3 The role of extracellular matrix for successful islet transplantation
Ekaterine Berishvili, Switzerland
293.1 Overview of islet transplantation
Camillo Ricordi, United States
293.2 Islet transplantation and inflammation
Maria Koulmanda, United States

Tue Sep 15

14:30 - 15:15 Oral Abstracts Session: Stem Cell Transplantation and Xenotransplantation
384.2 Quantifying the immune response to tissue engineered extracellular matrix
Ryaan EL-Andari, Canada
384.1 Simple Limbal Epithelial Transplantation (SLET) in a patient with limbal stem cell deficiency
Dilek Dursun Altinors, Turkey
384.3 Successful long-term TMA- and rejection-free survival of a kidney xenograft with triple xenoantigen knockout plus insertion of multiple human transgenes
David Ma, United States
384.4 Evidence for GTKO/β4GalNT2KO pigs as the preferred organ-source for old world monkeys as a preclinical model of xenotransplantation instead of triple-knockout pigs
Takayuki Yamamoto, United States
15:15 - 17:00 Workshop Session: Novel Strategies in Support to Hepatocyte Transplant
394.4 Human liver stem cell-derived extracellular vesicles
Giovanni Camussi, Italy
394.2 Hepatic spheroids
Volker Lauschke, Sweden
394.1 Hepatocyte transplantation overview
Anil Dhawan, United Kingdom
23:30 - 00:15 Oral Abstracts Session: Cell and Novel Therapies
412.1 Human mesenchymal-stem-cells derived exosomes play important roles in enhancing CB-treg suvival and functional stability
Juan Zhang, People's Republic of China
412.3 Targeting CD4+ T cell metabolism provides an effective and age-specific immunosuppression
Yeqi Nian, People's Republic of China
412.2 Phase 2 study design evaluating efficacy, safety, pharmacokinetics and pharmacodynamics of the anti-CD40 monoclonal antibody CFZ533 (iscalimab) in de novo liver transplant recipients: The CONTRAIL I study
Björn Nashan, Germany
412.4 Long-term follow-up of a phase 2 clinical trial to induce tolerance in living donor renal transplant recipients
Joseph R. Leventhal, United States

Wed Sep 16

15:15 - 17:00 State-of-the-Art Session: Beta Cell Replacement for the Future: Views from the Three Musketeers
492.1 The view from endocrinology
Eelco J..P de Koning, Netherlands
492.2 The view from surgery
Silke V. Niederhaus, United States
492.3 The view from regenerative medicine
Giuseppe Orlando, United States

E-Posters

Poster Session: Basic and Translational Sciences
P-2.02 B-cell depletion with anti-CD20 mAb exacerbates anti-donor CD4 positive T-Cell responses in highly sensitized transplant model
Asuka Tanaka, Japan
P-2.03 Noninvasive genotyping of donor’s HLA in kidney transplant patients by target capture sequencing
Liu Feng, People's Republic of China
P-2.04 Clinical significance of pretransplant donor-specific HLA antibodies in kidney transplant recipients of hispanic population
Idalia Parra-Avila, Mexico
P-2.05 Female complexity: High ‘natural’ ABO anti-A antibodies and IgG class switch in female vs male mice
Bushra Anjum, Canada
P-2.10 Immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma patients as a basis for early vaccination with T-cell dependent vaccines
Igor Stoma, Belarus
P-2.11 Imbalance favouring follicular helper T cells over IL10+ regulatory B cells is detrimental for the renal allograft
Alberto Utrero-Rico, Spain
P-2.13 Extracellular vesicles from urine as biomarkers of kidney allograft injury: optimization of extracellular vesicle isolation and characterization
Ivana Sedej, Slovenia
P-2.14 Establishment of early warning model of acute rejection in combination with HLA-G 14-bp gene polymorphism, serum KIM-1and OPN
Zhankui Jin, People's Republic of China
P-2.15 Immunosuppression affects circulating follicular regulatory T cells in kidney transplant recipients
Carla C. Baan, Netherlands
P-2.16 The use of dd-cfDNA as a predictive tool for future proteinuria
Thierry Viard, United States
P-2.17 Characterization of an integrative prognostic score for US patients taken from the DART study
Thierry Viard, United States
P-2.18 dd-cfDNA as a risk factor for initiating de-novo donor specific antibodies in heart transplantation
Thierry Viard, United States
P-2.19 Factors influencing background cell-free DNA levels: Implications for donor derived cell-free DNA assessment in transplant patients
Trudy McKanna, United States
P-2.20 Anti-rejection therapy does not eliminate donor-reactive IFN-γ and IL-21 producing cells
Nicole M. van Besouw, Netherlands
P-2.22 Use of dd-cfDNA as a surrogate marker of injury following hypothermic machine perfusion
Thierry Viard, United States
P-2.23 Establishment of early diagnostic model of acute rejection in combination with IL-2, IL-6, TNF-α and IFN-γ
Zhankui Jin, People's Republic of China
P-2.24 Incidence and risk factors of new onset diabetes after solid organ transplantation: Baskent University experience
Didem Turgut, Turkey
P-2.25 Value of dd-cfDNA when considering recipient ethnicity to further to help risk stratify transplant recipients
Thierry Viard, United States
P-2.26 Long-lasting effects of anti-rejection therapy on natural antibodies and alloreactive T cells in kidney transplant patients
Nicole M. van Besouw, Netherlands
P-2.27 Podocyte-specific urinary extracellular vesicles: A novel biomarker for recurrent primary focal segmental glomerulosclerosis after kidney transplantation
Hien Lau, United States
P-2.29 The relationship between myocardial fibrosis and plasma level of galectin-3 in heart transplant recipients underwent acute rejection
Rivada Kurabekova, Russian Federation
P-2.30 Do the blood groups and HLA types have a role in end stage chronic renal failure pathogenesis? A comparative retrospective single-center study
Ugur Musabak, Turkey
P-2.31 Immune signs of accommodation in kidney transplant recipients
Maciej Zieliński, Poland
P-2.32 Spot urine protein excretion during the first year after kidney transplantation associates with allograft rejection phenotype at 1-year surveillance biopsies: An observational national-cohort study
Miha Arnol, Slovenia
P-2.33 The utility of QuantiFERON monitoring based assay in assessing clinical events among kidney transplant recipients
Maisarah Jalalonmuhali, Malaysia
P-2.36 Early post-transplant infusion of ex vivo-expanded autologous polyclonal regulatory T cells (Treg) prolongs kidney allograft survival in nonlymphodepleted, CTLA4Ig-treated rhesus monkeys<span class="uk-margin-small-right" uk-icon="video-camera"></span>
Kazuki Sasaki, United States
P-2.37 IL-21 as a new target for immunosuppressive therapies
Carla C. Baan, Netherlands
P-2.38 The small-molecule BCL6-inhibitor 79-6 suppresses follicular T helper cell differentiation and plasma blast formation
Rens Kraaijeveld, Netherlands
P-2.39 Intra-lymph node delivery of macroparticles loaded with rapamycin in non-human primates
Zahra Habibabady, United States
P-2.40 Clinical-experimental experience with rapamycin in visceral transplantation
Javier Serradilla, Spain
P-2.41 The effects of a novel drug, PQA 18, on small intestinal transplantation
Tasuku Kodama, Japan
P-2.45 Cyclic helix B peptide ameliorates renal fibrosis induced by unilateral ureter obstruction via inhibiting NLRP3 pathway
Cheng Yang, People's Republic of China
P-2.47 The preventive effect of sirolimus on ureteral stricture formation
Sanem Cimen, Turkey
P-2.49 Primate tolerance model demonstrates longer kidney graft survival with the administration of polyclonal ex-vivo expanded Tregs
Karina Bruestle, United States
P-2.50 IL-4 regulates the secretion of IL-10 by human B cells
Griffith Perkins, Australia
P-2.51 Immunomodulation with SA-PDL1 protein on pancreatic islets promotes indefinite graft survival in allogeneic recipients
Esma ESY Yolcu, United States
P-2.53 Anti-IL-6 antibody reduces endothelial mediated pro-inflammatory responses and after binding of HLA-specific DSA to endothelial cells
Nuala Mooney, France
P-2.54 Preclinical study for tolerance induction to liver allografts with rapid immunosuppression withdrawal in Cynomolgus monkeys
Hiroshi Sakai, United States
P-2.55 Strong engagement of Cd137 suppresses graft-versus-host disease through dendritic cells
Sang Jun Park, Korea
P-2.59 The requirement of thymic irradiation for induction of mixed chimerism and renal allograft tolerance in non-human primates
Takayuki Hirose, United States
P-2.60 Experimental evidence on the role of the spleen in graft versus host disease after visceral transplantation
Pablo Stringa, Argentina
P-2.61 Comparison between vitamin C-treated induced-regulatory T cells and conventional induced-regulatory T cells in suppressing heart allograft rejection in either vitamin C-sufficient or vitamin C-deficient conditions
Juhee Hwang, Korea
P-2.62 Advantages of rhesus macaques in a tolerance model for combined bone marrow and kidney transplantation
Karina Bruestle, United States
P-2.63 siRNA gene knockdown with functionalised porous silicon nanoparticles
Sebastian O Stead, Australia
P-2.66 Class II HLA eplet mismatch is related to anti-donor CD4+ T cell response and de novo donor-specific antibody development in kidney transplantation recipient
Hiroaki Yamane, Japan
P-2.70 Changes in phenotype of human CD4+CD25+CD127lo Treg subpopulations after culture with rIL-2 and alloantigen
Nirupama D Verma, Australia
P-2.73 Mobilization of mast cells and regulatory t-cells by tetrahydrobiopterin is associated with prolonged allograft survival
Manuel Maglione, Austria
P-2.82 INT 767 – A novel dual farnesoid-X receptor (FXR) and takeda G-protein-coupled receptor-5 (TGR5) agonist attenuates intestinal ischemia reperfusion injury
Emilio Canovai, Belgium
P-2.84 High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injury
Cheng Yang, People's Republic of China
P-2.85 Mesenchymal stem cell-derived exosomes suppress of NLRP3 inflammasome activation to enhance anti-anoxic ability of porcine islets
Wei Nie, People's Republic of China
P-2.95 A novel rodent model of severe renal ischemia reperfusion injury that better mimics the renal transplant recipient
Ryan Ghita, United Kingdom
P-2.96 Ischemic preconditioning ameliorates renal ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy in mice
Jeongkye Hwang, Korea
P-2.99 In-depth assessment of ischemia/reperfusion injury in a murine model of hindlimb transplantation
Franka Messner, Austria
P-2.103 Ischemic preconditioning attenuates renal ischemia-reperfusion injury by TLR4 suppression and eNOS activation
Jeongkye Hwang, Korea
P-2.104 The impact of oxygen free radical scavenger on acute rejection in a histocompatible miniature swine model
Philipp Tratnig-Frankl, United States
P-2.105 The tissue Common Response Module (tCRM) score provides a quantitative objective biopsy score to assess the severity of pancreas transplant rejection
Yvonne Kelly, United States
P-2.107 Increased level of serum cholesterol and apoptosis together induces the development of liver fibrosis and early allograft loss
Binnaz Handan Ozdemir, Turkey
P-2.108 Analyzing interactions between donor endothelium and recipient blood under flow conditions in vitro
Margaret Connolly, United States
P-2.113 Influence of β-Catenin on the proliferation of vascular smooth muscle cells and the development of cardiac allograft vasculopathy in mice
Christian Heim, Germany
P-2.115 Recipient bone marrow Treg; major players in transplant tolerance
Amy Prosser, Australia
P-2.116 High-fibre diet reduces transplant-associated dysbiosis and improves renal allograft survival in a murine model of kidney allograft rejection
Julian Singer, Australia
P-2.119 Gut microbiome dynamics over a course of kidney transplantation: Preliminary results of a pilot study
Igor Stoma, Belarus
P-2.121 Characterization of donor and recipient myeloid cells following congenic and allogeneic liver transplantation
Sarah J Dart, Australia
P-2.122 Preparation of transplantable acellular scleral graft using porcine eye
Kyungmee Park, Korea
P-2.123 Preparation of ultra-thin descemet's membrane graft using decellularized porcine cornea
Kyungmee Park, Korea
P-2.124 NK cell exhaustion facilitates tumor recurrence after liver transplantation via the TLR4 / HLA-E signaling pathway
Xinxiang Yang, People's Republic of China
P-2.126 Assessment of HLA typing performance of Korea Biobank Array for transplantation genome-wide association study in Koreans
Young Jin Kim, Korea
P-2.129 A genome-wide association study identified genetic loci for end-stage renal disease in the Korean population
Young Jin Kim, Korea
P-2.130 Vascular endothelial growth factor (vegf) 936 C/T gene polymorphism in renal transplant recipients: Association with graft rejection and final graft outcome
Manzoor Parry, India
P-2.131 Lymphotoxin beta receptor regulates Treg stability, migration, and function
Vikas Saxena, United States
P-2.133 Liver tissue-resident lymphocytes are significantly heterogeneous, and the original repertoire is not recreated by infiltrating recipient cells
Amy Prosser, Australia
P-2.137 Ischemic and perfused kidney treated with non-cultured adipose-derived regenerative cells increase the immune and regulatory transcriptome
Ryan Ghita, United Kingdom
Poster Session: Cellular and Regenerative Therapies
P-3.06 Generation of stable human induced regulatory T-cells requires optimal rapamycin concentration and TCR stimulation
Juewan Kim, Australia
P-3.11 Small-for-size syndrome is characterized with PD-L1 upregulation in macrophage and blocking PD-L1 accelerates liver regeneration
Ji-Hua Shi, People's Republic of China
P-3.14 Directed differentiation of iPS into imDCs under the action of SN can induce immunoreactivity in vitro
Cuixiang Xu, People's Republic of China
P-3.15 Sinomenine enhances imDC derived from IPS cell-directed differentiation to induce transplant immune hyporesponsiveness in mouse
Cuixiang Xu, People's Republic of China
P-3.03 Cell therapy using CD8+Tregs in human transplantation
Séverine Bézie, France
P-3.10 Bile duct reconstruction using scaffold-free tubular constructs created by a Bio-3D Printer for transplantation
Takashi Hamada, Japan
P-3.13 Visual rehabilitation after penetrating keratoplasty
Leyla Asena, Turkey
P-3.16 Limbal stem cell transplantation for restoration of the ocular surface health in bilateral limbal stem cell deficiency
Dilek Dursun Altinors, Turkey
P-3.01 Mass Cytometry Analysis of the Peripheral Regulatory T cell Compartment after Cellular Therapy in Renal Transplantation
Alaa Alzhrani, United Kingdom
P-3.08 Successful induction of hematopoietic chimerism by MCL-1 and Bcl-2 inhibition without radiation/chemo therapy in nonhuman primates
David Ma, United States
Poster Session: Pancreas and Islet
P-14.02 The expression of cadherins in the development of neonatal pig islets post-transplantation
Wenlong Huang, Canada
P-14.11 Bone marrow mesenchymal stem cells inhibit the effect of TIMP3 by transmitting miR-21-5p, thus improving the angiogenesis of rat islets
Jingwen Wang, People's Republic of China
P-14.12 Upregulation of islet-1 in islets co-cultured with bone marrow mesenchymal stem cells promotes angiogenesis through NF-κB pathways
Ying Wang, People's Republic of China
P-14.09 The advanced mechanisms of islet-engraftment onto white adipose tissue
Naoaki Sakata, Japan
P-14.15 Efficacy and safety of islet transplantation in patients with type 1 diabetes: A Japanese single-center experience
Takayuki Anazawa, Japan
P-14.16 Inhibition of NLRP3 inflammasome reduces apoptosis of islets and migration of macrophages after islet transplantation
Taisuke Matsuoka, Japan
P-14.10 Islet isograft transplantation improves insulin sensitivity in type 2 diabetes mice induced by high fat diet combined with low-dose streptozotocin
Sung Shin, Korea
P-14.14 Durable effect of beta cell replacement therapy on improvement in blood glucose control and prevention of progression of secondary diabetic complications in nonuremic patients with type 1 diabetes mellitus and problematic hypoglycemia
Piotr J Bachul, United States
P-14.19 How we achieved 0% of thrombotic graft loss -The initial 60 cases of pancreas transplant
Byung-Hyun Choi, Korea
P-14.24 Beneficial effects of post-transplant dipeptidyl peptidase administration early after pancreas transplantation to improve β cell function
Sung Shin, Korea
P-14.17 Lower extremity vascular complications after simultaneous pancreas kidney transplant
Hillary J Braun, United States

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