| 22:00 - 23:30 | Workshop Session: Design of Xenotransplantation Clinical Trials |
| 201.3 |
Encapsulated islets Shinichi Matsumoto, Japan |
| 201.1 |
Cornea Chang Ho Yoon, Korea |
| 201.2 |
Naked islets Kwang-Won Kim, Korea |
| 201.4 |
Kidney Alfred Joseph Tector, United States |
| 23:30 - 00:15 | Oral Abstracts Session: Innate and Adaptive Immunity |
| 211.1 |
Gasdermin-D mutation is protective against renal ischemia reperfusion injury Jennifer Li, Australia |
| 211.5 (P-2.74 in Journal) |
Oral administration of nano-sized silicon particles attenuates oxidative stress and ischemia-reperfusion injury in a rat model: A novel hydrogen administration method Masataka Kawamura, Japan |
| 211.3 |
Modulation of the IL-33/ST2 axis for regulatory T cell therapy in transplantation Kento Kawai, United Kingdom |
| 211.4 |
Development of fully differentiated pancreatic organoids from hiPSCs for type 1 diabetes cell therapy Giuseppe Pettinato, United States |
| 00:15 - 02:00 | State-of-the-Art Session: Tissue-Resident Lymphocytes |
| 220.1 |
Formation and plasticity of tissue resident memory populations in human allografts revealed by single cell analysis and serial TCR sequencing Megan Sykes, United States |
| 220.2 |
Antigen presentation by tissue resident APC Adrian E. Morelli, United States |
| 220.3 |
Reshaping T cell memory with lymphoablation Anna Valujskikh, United States |
| 07:30 - 08:15 | Oral Abstracts Session: Immune Regulation and Outcomes |
| 251.2 |
Discovery of pMHC epitopes for directly alloreactive T cells Eric Taeyoung ES Son, Australia |
| 251.3 |
The Prediction of Kidney Allograft Acute Rejection Based on Recipient Peripheral Blood Whole Transcriptome Profiling and Three mRNA Molecular Signatures Liao Minxue, People's Republic of China |
| 251.1 |
Elucidating the role of hypoxia in regulatory T cell function Marie Sion, United Kingdom |
| 13:00 - 14:30 | Workshop Session: What is the Ideal Pig for Xenotransplantation? / Carl-Gustav Groth Xeno Prize |
| 276.1 |
Are remaining xeno-antigens relevant? Alfred Joseph Tector, United States |
| 276.2 |
The ideal modified pig, how many genes are necessary? Eckhard Wolf, Germany |
| 276.3 |
Do we need to address p?hysiologic incompatibilities David K. C. Cooper, United States |
| 276.4 |
Xeno-organ growth: myth or reality? Matthias Längin, Germany |
| 276.5 |
Presentation of the Carl-Gustav Groth Xeno Prize to Joachim Hundrieser Agnes Azimzadeh, United States |
| 14:30 - 15:15 | Oral Abstracts Session: Xenotransplantation Abstract Session |
| 283.2 |
Prolonged survival and attenuated pulmonary vascular resistance rise in a multitransgenic pig ex vivo lung xenoperfusion model Margaret Connolly, United States |
| 283.3 |
Prolonged survival of genetically modified pig livers during machine perfusion with human blood Taylor Coe, United States |
| 283.4 |
Humanized von Willebrand factor reduces platelet sequestration in pig xenogeneic lung perfusion and pig-to-primate lung transplantation Margaret Connolly, United States |
| 15:15 - 17:00 | State-of-the-Art Session: Islet Transplantation Up-to-Date |
| 293.3 |
The role of extracellular matrix for successful islet transplantation Ekaterine Berishvili, Switzerland |
| 293.1 |
Overview of islet transplantation Camillo Ricordi, United States |
| 293.2 |
Islet transplantation and inflammation Maria Koulmanda, United States |
| 23:30 - 00:15 | Oral Abstracts Session: Experimental and Preclinical Immunosuppression |
| 312.2 |
Targeting inflammatory monocytes by immune-modifying nanoparticles prevents acute kidney allograft rejection Christina Lai, Australia |
| 312.4 |
ABO self-tolerance in a mouse model: Evidence of tolerance at B cell but not T cell level Ibrahim Adam, Canada |
| 312.3 |
Carfilzomib and lulizumab-based desensitization prolongs allograft survival in sensitized non-human primates kidney transplantation model Jean Kwun, United States |
| 06:00 - 07:30 | Workshop Session: Regulation of Xenotransplantation |
| 341.4 |
Update on the Changsha Communiques Wayne J. Hawthorne, Australia |
| 341.2 |
Regulation in China Shaoping Deng, People's Republic of China |
| 341.1 |
Regulation in Korea Ivo Kwon, Korea |
| 341.3 |
Regulating Safety: what’s new? Linda Scobie, United Kingdom |
| 07:30 - 08:15 | Oral Abstracts Session: Kidney Transplantation: Ischemia/reperfusion injury and long-term graft outcomes |
| 350.1 |
Role of IL-6 and IL-17 mediated inflammation amplifier loop in Chronic Antibody-Mediated Rejection (CABMR) Mantabya Kumar Singh, India |
| 350.2 |
A biocompatible nanoparticle-based approach to inhibiting renal ischemia reperfusion injury in mice by blocking thrombospondin-1 activity Tianmeng Sun, People's Republic of China |
| 350.4 |
Impact of acute kidney injury on graft outcomes in deceased donor kidney transplantation: A nationwide registry-based matched cohort study in Korea Jane Ha, Korea |
| 350.5 (P-2.81 in Journal) |
A point mutation of SHROOM3 promotes CD206+ macrophage infiltration and kidney fibrosis after ischemia-reperfusion injury Tianfeng Tang, People's Republic of China |
| 14:30 - 15:15 | Oral Abstracts Session: Immune Regulation and Tolerance I |
| 381.1 |
Treg use the PD-1-PD-L1 axis for lymphatic transendothelial migration Wenji Piao, United States |
| 381.2 |
Donor liver plasmacytoid dendritic cells promote effector T cell exhaustion and augment Treg responses in mouse spontaneous liver transplant tolerance Ryosuke Nakano, United States |
| 381.3 |
Lymph node stromal laminin alpha 5 regulates adaptive immunity Lushen Li, United States |
| 14:30 - 15:15 | Oral Abstracts Session: Stem Cell Transplantation and Xenotransplantation |
| 384.2 |
Quantifying the immune response to tissue engineered extracellular matrix Ryaan EL-Andari, Canada |
| 384.1 |
Simple Limbal Epithelial Transplantation (SLET) in a patient with limbal stem cell deficiency Dilek Dursun Altinors, Turkey |
| 384.3 |
Successful long-term TMA- and rejection-free survival of a kidney xenograft with triple xenoantigen knockout plus insertion of multiple human transgenes David Ma, United States |
| 23:30 - 00:15 | Oral Abstracts Session: Cell and Novel Therapies |
| 412.1 |
Human mesenchymal-stem-cells derived exosomes play important roles in enhancing CB-treg suvival and functional stability Juan Zhang, People's Republic of China |
| 412.3 |
Targeting CD4+ T cell metabolism provides an effective and age-specific immunosuppression Yeqi Nian, People's Republic of China |
| 412.4 |
Long-term follow-up of a phase 2 clinical trial to induce tolerance in living donor renal transplant recipients Joseph R. Leventhal, United States |
| 07:30 - 08:15 | Oral Abstracts Session: Immune Regulation and Tolerance II |
| 451.3 |
PD-L1 / PD-1 interactions are critical for tolerance induction in primed skin graft recipients following liver-directed MHC class I gene transfer Mario L Leong, Australia |
| 451.2 |
Identification and isolation of human HLADR+ CD27+ Treg as xeno-antigen Treg subset for xenotransplantation Xiaoqian Ma, People's Republic of China |
| 451.1 |
Transient antibody targeting of CD45RC to prevent the development of acute graft versus host diseases Carole Guillonneau, France |
| 451.4 |
CTLA-4-Ig prolongs graft survival specifically in young but not in old recipients Jasper Iske, Germany |
| 08:15 - 10:00 | State-of-the-Art Session: Recent Breakthroughs in Xenogeneic Tissue and Organ Transplantation |
| 462.1 |
Heart Paolo Brenner, Germany |
| 462.3 |
Islets Chung-Gyu Park, Korea |
| 462.4 |
Cornea Mee Kum Kim, Korea |
| 462.2 |
Kidney Kazuhiko Yamada, United States |
| Poster Session: Basic and Translational Sciences |
| P-2.02 |
B-cell depletion with anti-CD20 mAb exacerbates anti-donor CD4 positive T-Cell responses in highly sensitized transplant model Asuka Tanaka, Japan |
| P-2.03 |
Noninvasive genotyping of donor’s HLA in kidney transplant patients by target capture sequencing Liu Feng, People's Republic of China |
| P-2.04 |
Clinical significance of pretransplant donor-specific HLA antibodies in kidney transplant recipients of hispanic population Idalia Parra-Avila, Mexico |
| P-2.05 |
Female complexity: High ‘natural’ ABO anti-A antibodies and IgG class switch in female vs male mice Bushra Anjum, Canada |
| P-2.10 |
Immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma patients as a basis for early vaccination with T-cell dependent vaccines Igor Stoma, Belarus |
| P-2.11 |
Imbalance favouring follicular helper T cells over IL10+ regulatory B cells is detrimental for the renal allograft Alberto Utrero-Rico, Spain |
| P-2.13 |
Extracellular vesicles from urine as biomarkers of kidney allograft injury: optimization of extracellular vesicle isolation and characterization Ivana Sedej, Slovenia |
| P-2.14 |
Establishment of early warning model of acute rejection in combination with HLA-G 14-bp gene polymorphism, serum KIM-1and OPN Zhankui Jin, People's Republic of China |
| P-2.15 |
Immunosuppression affects circulating follicular regulatory T cells in kidney transplant recipients Carla C. Baan, Netherlands |
| P-2.16 |
The use of dd-cfDNA as a predictive tool for future proteinuria Thierry Viard, United States |
| P-2.17 |
Characterization of an integrative prognostic score for US patients taken from the DART study Thierry Viard, United States |
| P-2.18 |
dd-cfDNA as a risk factor for initiating de-novo donor specific antibodies in heart transplantation Thierry Viard, United States |
| P-2.19 |
Factors influencing background cell-free DNA levels: Implications for donor derived cell-free DNA assessment in transplant patients Trudy McKanna, United States |
| P-2.20 |
Anti-rejection therapy does not eliminate donor-reactive IFN-γ and IL-21 producing cells Nicole M. van Besouw, Netherlands |
| P-2.22 |
Use of dd-cfDNA as a surrogate marker of injury following hypothermic machine perfusion Thierry Viard, United States |
| P-2.23 |
Establishment of early diagnostic model of acute rejection in combination with IL-2, IL-6, TNF-α and IFN-γ Zhankui Jin, People's Republic of China |
| P-2.24 |
Incidence and risk factors of new onset diabetes after solid organ transplantation: Baskent University experience Didem Turgut, Turkey |
| P-2.25 |
Value of dd-cfDNA when considering recipient ethnicity to further to help risk stratify transplant recipients Thierry Viard, United States |
| P-2.26 |
Long-lasting effects of anti-rejection therapy on natural antibodies and alloreactive T cells in kidney transplant patients Nicole M. van Besouw, Netherlands |
| P-2.27 |
Podocyte-specific urinary extracellular vesicles: A novel biomarker for recurrent primary focal segmental glomerulosclerosis after kidney transplantation Hien Lau, United States |
| P-2.29 |
The relationship between myocardial fibrosis and plasma level of galectin-3 in heart transplant recipients underwent acute rejection Rivada Kurabekova, Russian Federation |
| P-2.30 |
Do the blood groups and HLA types have a role in end stage chronic renal failure pathogenesis? A comparative retrospective single-center study Ugur Musabak, Turkey |
| P-2.31 |
Immune signs of accommodation in kidney transplant recipients Maciej Zieliński, Poland |
| P-2.33 |
The utility of QuantiFERON monitoring based assay in assessing clinical events among kidney transplant recipients Maisarah Jalalonmuhali, Malaysia |
| P-2.37 |
IL-21 as a new target for immunosuppressive therapies Carla C. Baan, Netherlands |
| P-2.38 |
The small-molecule BCL6-inhibitor 79-6 suppresses follicular T helper cell differentiation and plasma blast formation Rens Kraaijeveld, Netherlands |
| P-2.39 |
Intra-lymph node delivery of macroparticles loaded with rapamycin in non-human primates Zahra Habibabady, United States |
| P-2.40 |
Clinical-experimental experience with rapamycin in visceral transplantation Javier Serradilla, Spain |
| P-2.41 |
The effects of a novel drug, PQA 18, on small intestinal transplantation Tasuku Kodama, Japan |
| P-2.45 |
Cyclic helix B peptide ameliorates renal fibrosis induced by unilateral ureter obstruction via inhibiting NLRP3 pathway Cheng Yang, People's Republic of China |
| P-2.47 |
The preventive effect of sirolimus on ureteral stricture formation Sanem Cimen, Turkey |
| P-2.49 |
Primate tolerance model demonstrates longer kidney graft survival with the administration of polyclonal ex-vivo expanded Tregs Karina Bruestle, United States |
| P-2.50 |
IL-4 regulates the secretion of IL-10 by human B cells Griffith Perkins, Australia |
| P-2.51 |
Immunomodulation with SA-PDL1 protein on pancreatic islets promotes indefinite graft survival in allogeneic recipients Esma ESY Yolcu, United States |
| P-2.53 |
Anti-IL-6 antibody reduces endothelial mediated pro-inflammatory responses and after binding of HLA-specific DSA to endothelial cells Nuala Mooney, France |
| P-2.54 |
Preclinical study for tolerance induction to liver allografts with rapid immunosuppression withdrawal in Cynomolgus monkeys Hiroshi Sakai, United States |
| P-2.55 |
Strong engagement of Cd137 suppresses graft-versus-host disease through dendritic cells Sang Jun Park, Korea |
| P-2.59 |
The requirement of thymic irradiation for induction of mixed chimerism and renal allograft tolerance in non-human primates Takayuki Hirose, United States |
| P-2.60 |
Experimental evidence on the role of the spleen in graft versus host disease after visceral transplantation Pablo Stringa, Argentina |
| P-2.62 |
Advantages of rhesus macaques in a tolerance model for combined bone marrow and kidney transplantation Karina Bruestle, United States |
| P-2.63 |
siRNA gene knockdown with functionalised porous silicon nanoparticles Sebastian O Stead, Australia |
| P-2.66 |
Class II HLA eplet mismatch is related to anti-donor CD4+ T cell response and de novo donor-specific antibody development in kidney transplantation recipient Hiroaki Yamane, Japan |
| P-2.70 |
Changes in phenotype of human CD4+CD25+CD127lo Treg subpopulations after culture with rIL-2 and alloantigen Nirupama D Verma, Australia |
| P-2.73 |
Mobilization of mast cells and regulatory t-cells by tetrahydrobiopterin is associated with prolonged allograft survival Manuel Maglione, Austria |
| P-2.82 |
INT 767 – A novel dual farnesoid-X receptor (FXR) and takeda G-protein-coupled receptor-5 (TGR5) agonist attenuates intestinal ischemia reperfusion injury Emilio Canovai, Belgium |
| P-2.84 |
High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injury Cheng Yang, People's Republic of China |
| P-2.85 |
Mesenchymal stem cell-derived exosomes suppress of NLRP3 inflammasome activation to enhance anti-anoxic ability of porcine islets Wei Nie, People's Republic of China |
| P-2.95 |
A novel rodent model of severe renal ischemia reperfusion injury that better mimics the renal transplant recipient Ryan Ghita, United Kingdom |
| P-2.96 |
Ischemic preconditioning ameliorates renal ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy in mice Jeongkye Hwang, Korea |
| P-2.99 |
In-depth assessment of ischemia/reperfusion injury in a murine model of hindlimb transplantation Franka Messner, Austria |
| P-2.103 |
Ischemic preconditioning attenuates renal ischemia-reperfusion injury by TLR4 suppression and eNOS activation Jeongkye Hwang, Korea |
| P-2.104 |
The impact of oxygen free radical scavenger on acute rejection in a histocompatible miniature swine model Philipp Tratnig-Frankl, United States |
| P-2.105 |
The tissue Common Response Module (tCRM) score provides a quantitative objective biopsy score to assess the severity of pancreas transplant rejection Yvonne Kelly, United States |
| P-2.107 |
Increased level of serum cholesterol and apoptosis together induces the development of liver fibrosis and early allograft loss Binnaz Handan Ozdemir, Turkey |
| P-2.108 |
Analyzing interactions between donor endothelium and recipient blood under flow conditions in vitro Margaret Connolly, United States |
| P-2.113 |
Influence of β-Catenin on the proliferation of vascular smooth muscle cells and the development of cardiac allograft vasculopathy in mice Christian Heim, Germany |
| P-2.115 |
Recipient bone marrow Treg; major players in transplant tolerance Amy Prosser, Australia |
| P-2.116 |
High-fibre diet reduces transplant-associated dysbiosis and improves renal allograft survival in a murine model of kidney allograft rejection Julian Singer, Australia |
| P-2.119 |
Gut microbiome dynamics over a course of kidney transplantation: Preliminary results of a pilot study Igor Stoma, Belarus |
| P-2.121 |
Characterization of donor and recipient myeloid cells following congenic and allogeneic liver transplantation Sarah J Dart, Australia |
| P-2.122 |
Preparation of transplantable acellular scleral graft using porcine eye Kyungmee Park, Korea |
| P-2.123 |
Preparation of ultra-thin descemet's membrane graft using decellularized porcine cornea Kyungmee Park, Korea |
| P-2.124 |
NK cell exhaustion facilitates tumor recurrence after liver transplantation via the TLR4 / HLA-E signaling pathway Xinxiang Yang, People's Republic of China |
| P-2.126 |
Assessment of HLA typing performance of Korea Biobank Array for transplantation genome-wide association study in Koreans Young Jin Kim, Korea |
| P-2.129 |
A genome-wide association study identified genetic loci for end-stage renal disease in the Korean population Young Jin Kim, Korea |
| P-2.130 |
Vascular endothelial growth factor (vegf) 936 C/T gene polymorphism in renal transplant recipients: Association with graft rejection and final graft outcome Manzoor Parry, India |
| P-2.131 |
Lymphotoxin beta receptor regulates Treg stability, migration, and function Vikas Saxena, United States |
| P-2.133 |
Liver tissue-resident lymphocytes are significantly heterogeneous, and the original repertoire is not recreated by infiltrating recipient cells Amy Prosser, Australia |
| P-2.137 |
Ischemic and perfused kidney treated with non-cultured adipose-derived regenerative cells increase the immune and regulatory transcriptome Ryan Ghita, United Kingdom |
| Poster Session: Xenotransplantation |
| P-21.01 |
Identification of a novel subset of xeno-antigen specific memory CD4+Foxp3+Tregs in islet-xenotransplant tolerance Leigh Nicholson, Australia |
| P-21.19 |
Selection of immunosuppressive drugs for Cord blood derived xenoantigen-stimulated Treg he xing, People's Republic of China |
| P-21.11 |
Microcapsule against hypoxia showed longer graft survival than microcapsule against fibrosis in diabetic mice receiving GalT-KO porcine islet transplantation Eun Young Lee, Korea |
| P-21.15 |
Serological cytokine changes in nonhuman-primate recipients after porcine cardiac xenotransplantation Hee Jung Kang, Korea |
| P-21.17 |
Pre-clinical results of porcine islet re-transplantation after first porcine islet transplantation in rhesus monkeys Jong-Min Kim, Korea |
| P-21.20 |
Selected sequences of porcine elongation factor 1 alpha promoter lead to significant upregulation of target gene responding to human serum induction in porcine cells Keon B Oh, Korea |
| P-21.14 |
CD177 on swine cells suppresses xenogeneic macrophage-mediated cytotoxicity Pei-Chi Lo, Taiwan |
| P-21.02 |
Lack of human thrombomodulin gene expression in life supporting pig-to-baboon cardiac xenotransplantation models may accelerate antibody mediated rejection Corbin Goerlich, United States |
| P-21.03 |
Expression of human thrombomodulin gene on genetically engineered pig hearts prolong cardiac xenograft survivals in non-human primates Avneesh Singh, United States |
| P-21.07 |
Beta4GalKO reduces anti-non Gal antibody binding in pig-to-baboon and pig-to-human lung transplantation models Lars Burdorf, United States |
| P-21.08 |
Genetic modifications of the porcine genome regulate inflammatory and coagulation responses during ex-vivo porcine liver perfusion with human blood Nikolaos Serifis, United States |
| P-21.09 |
Community perceptions and attitudes towards xenotransplantation in preparation for clinical trials Luz A Padilla, United States |
| P-21.10 |
Survival Benefit of Pig-to-Baboon Liver Xenotransplantation Utilizing Genetically Modified Swine Taylor Coe, United States |
| P-21.12 |
Presence of graft-infiltrating regulatory T cells are associated with long term cardiac xenograft survival in non-human primate Avneesh Singh, United States |
| P-21.13 |
Genetic modifications attenuate but don’t abrogate the sialoadhesin-dependent adhesion of human RBC to porcine macrophages Kaitlyn Petitpas, United States |
| P-21.16 |
New world monkeys as models for testing triple-knockout (TKO) pig red blood cell or skin transplants Takayuki Yamamoto, United States |
| P-21.18 |
Xenogeneic lung perfusion using GalTKO.hCD46 lungs expressing hTFPI and hCD47 Lars Burdorf, United States |
